ABSTRACT
Warthin's tumor also known as papillary cystadenoma lymphomatosum is a common benign salivary gland neoplasm that occurs exclusively in parotid gland. Rarely, the tumor can undergo carcinomatous or lymphomatous transformation of epithelial or lymphoid component, respectively. Herein, we describe a case of 55-year-old female who had undergone parotidectomy for a rapidly growing tumor in the right parotid gland. The case was diagnosed as mucoepidermoid carcinoma developed in a setting of Warthin's tumor based on the histomorphology, special staining characters, and immunohistochemical findings. The pathogenesis and differential diagnoses of such rare malignancy has been discussed briefly.
Subject(s)
Adenolymphoma/complications , Adenolymphoma/diagnosis , Adenolymphoma/pathology , Adenolymphoma/surgery , Carcinoma, Mucoepidermoid/complications , Carcinoma, Mucoepidermoid/diagnosis , Carcinoma, Mucoepidermoid/pathology , Carcinoma, Mucoepidermoid/surgery , Female , Histocytochemistry , Humans , Microscopy , Middle Aged , Parotid Gland/pathology , Parotid Gland/surgery , Parotid Neoplasms/diagnosis , Parotid Neoplasms/pathology , Parotid Neoplasms/surgeryABSTRACT
Warthin tumor is a well-recognized benign salivary gland neoplasm consisting of an epithelial as well as a lymphoid component. Malignant transformation in Warthin tumor is rare and its reported incidence is up to 1%. The more common types of carcinomas described in Warthin tumor are the squamous and mucoepidermoid types, with high-grade adenocarcinoma being extremely rare. A high-grade adenocarcinoma (ductal type) arising in the Warthin tumor in a 72-year-old man is presented for its rarity and diagnostic difficulties.